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Novartis is closing MorphoSys sites in Munich and Boston, resulting in approximately 330 layoffs, as part of its integration strategy following the €2.7 billion acquisition earlier this year. The decision aligns with a focus on prioritizing R&D programs, particularly the delayed approval pathway for the oncology candidate pelabresib. This trend of post-acquisition job cuts has been observed across several major pharma companies in recent years.
The global gene therapy market, valued at $7.54 billion in 2022, is projected to reach $41.38 billion by 2031, driven by increased R&D, favorable regulations, and collaborations between pharmaceutical companies and academic institutions. North America leads the market, with significant advancements in biotechnology and numerous clinical trials. Recent developments include Novartis's acquisition of a gene therapy candidate from Avrobio and Bristol-Myers Squibb's expansion of its cell therapy manufacturing network.
U.S. stock indexes pulled back, with the S&P 500 down 0.4% and Nvidia's stock falling 1.2%, marking its eighth loss in nine days. Despite this, the S&P 500 is up nearly 27% for the year, buoyed by strong economic resilience and expectations of favorable policies from President-elect Trump. Bitcoin briefly surpassed $108,000 before retreating to around $106,500.
Roche has received EU approval for a prefilled syringe (PFS) of its ophthalmology drug Vabysmo, designed to treat neovascular age-related macular degeneration, diabetic macular edema, and macular edema following retinal vein occlusion. This PFS offers a convenient administration method for over 9 million affected individuals in the EU and is the first of its kind containing a bispecific antibody for these conditions. Following strong sales growth, the approval is expected to further enhance Roche's revenue amid increasing competition in the ophthalmology market.
In September, multiple biotech companies announced significant layoffs, with Inventprise cutting 7% of its workforce, bluebird bio reducing 25%, and Athira Pharma laying off 70% after a failed trial. Other notable reductions included Charles River Laboratories (3%), Cidara Therapeutics (30%), and Astellas Gene Therapies impacting around 100 employees. The trend reflects ongoing challenges in the biotech sector, with companies restructuring to focus on core projects and manage costs.
AbbVie's schizophrenia drug emraclidine failed two mid-phase trials, performing no better than placebo, resulting in a $40 billion market cap loss for the company. This setback follows the recent approval of Bristol Myers Squibb's Cobenfy, the first new schizophrenia drug in decades, which boosted BMS's share price by 12%. The failure raises concerns for other companies developing similar drugs in the same class.
The Breakthrough Therapies Market is projected to grow from USD 150.6 billion in 2024 to USD 287.5 billion by 2029, achieving a CAGR of 13.80%. The report analyzes risks, benefits, and competitive strategies related to breakthrough therapy designation across various therapeutic areas, including oncology and rare diseases, while profiling key market players and trends.
Bristol Myers Squibb has filed a lawsuit against the federal government over a rejected plan to implement a 340B rebate model for drug discounts to hospitals, claiming the decision by HHS was unlawful. The company argues that its model would enhance compliance and transparency while addressing issues of abuse within the program. BMS intends to start this model with its Eliquis product in spring 2025, despite HHS's disapproval citing statutory inconsistencies.
Amgen's MariTide obesity drug showed mid-stage trial results in line with competitors, while Stryker's Mako robotic product and outpatient focus position it as a strong investment. Pfizer's potential divestment of its hospital drugs business could enhance its core growth, and Boston Scientific's promising pipeline supports its long-term outlook. CFRA maintains "buy" ratings for these companies, with specific price targets reflecting their growth potential.
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